There is an increasing recognition that conflict is not gender neutral; in fact, protracted conflicts such as in Gaza create a landscape of multidimensional and intersectional vulnerabilities for diverse groups compounding over time (specifically around access to food, mobility, poverty, education, protection and employment) and disproportionately affect women and girls across all categories. The escalation of violence in Gaza and the surrounding region has led to an unfathomable level of death, deprivation and destruction for the most vulnerable populations and further compromises their ability to respond, adapt and build resilience to continued shock. Thus, the humanitarian response must account for these pre-existing vulnerabilities while integrating and adapting to the complexity of this unprecedented crisis through a gender and inclusive programming lens. This Rapid Gender Analysis (RGA) aims to highlight existing gender, age and disability data and provide operational recommendations for the humanitarian response in Gaza, while centering ‘Do No Harm’ principles. Given the rapidly evolving context of this crisis, this RGA brief draws from secondary data to inform immediate programming and will be updated as more information becomes available and more in-depth information is needed to support the humanitarian response.